I am now a fully integrated Mac and PC user. I found however that motor planning plays a part in one's Mac/PC experience because I am constantly annoyed that the Mac scroll wheel works counter intuitively. As a UI designer, the concept of scrolling the mousewheel towards me immediately equates with pulling the scroll-bar down, on a Mac, the process pulls the page down, effectively scrolling up.
When I switch from one system to the other with my handy-dandy TrendNet KVM switch I have a moment of confusion before I get reoriented again.
I reckoned that there must be a setting for this and so there was. On the Mac, the mouse options have a checkbox one can select.